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. 2021 Nov 16;11:745150. doi: 10.3389/fonc.2021.745150

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Copyright © 2021 Qian, Wang, Wang, Lu, Zhang, Zhang, Wang, Nie, Zhang, Lou and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between HbA1c level and OS as plotted through unadjusted and adjusted restricted cubic splines model. (A) model 1 (unadjusted), (B) model 2 (adjusted by stage, EGFR status, smoking history and first-line treatment). The middle red line indicates the point estimates of Log hazard ratios and the blue lines indicate the lower and upper limits of the corresponding 95% confidence intervals. The horizontal broken line is at hazard ratio=1 (logHR=0). A significant non-linear association was observed (A) P for non-linearity=0.0096, (B) P for non-linearity <0.001).