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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: ACS Nano. 2017 Jun 7;11(6):5417–5429. doi: 10.1021/acsnano.6b08152

Figure 4.

Figure 4.

Tumor-specific CD8+ tumor-infiltrating lymphocytes of immunoswitch treated mice have increased functionality. (a) C57BL/6 mice (n = 3/group) were injected with B16-SIY cells SC on day 0. Immunoswitch particles were injected IT on days 8 and 11. On day 14, tumor-infiltrating lymphocytes were harvested and restimulated with SIY pulsed RMA-S cells. Intracellular cytokine staining indicated an increased frequency of CD107 producing (a) and IFN-γ producing (b) CD8+ T cells following immunoswitch treatment. The mean fluorescence intensity (MFI) of IFN-γ+ cells was increased in treated mice. Significance was measured by one-tailed t test (*p < 0.05).