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. 2021 Nov 16;12:761450. doi: 10.3389/fimmu.2021.761450

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Copyright © 2021 Casali, Li, Morales, Daw, Chupp, Fisher and Zan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell miR-146a deficiency alters gut bacterial microbiome in μMT/miR-146a^–/– mice. Relative abundance of fecal bacteria families and genera (A, B) in μMT/miR-146a^–/– and μMT/miR-146a^+/+ chimeric mice (n = 3 per group) as determined by high-throughput 16s rRNA gene miSeq amplicon sequencing. (C) Frequency of five relatively abundant fecal bacteria families and genera in these mice. ***p < 0.001, **p < 0.01, ns, not significant, unpaired t-test. (D) Principal component analysis of gut bacterial composition of the fecal bacteria families and genera in μMT/miR-146a^–/– and μMT/miR-146a^+/+ chimeric mice. Data are from three independent experiments.