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. 2021 Nov 16;8:751637. doi: 10.3389/fmolb.2021.751637

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Copyright © 2021 Loaeza-Reyes, Zenteno, Moreno-Rodríguez, Torres-Rosas, Argueta-Figueroa, Salinas-Marín, Castillo-Real, Pina-Canseco and Cervera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Beneficial and detrimental effects of O-GlcNAcylation due to the timing of the modification and specific stimulus. (A) Some experiments that reflect effects under specific conditions of acute elevated O-GlcNAcylation on cardiomyocyte and aortic segments. (B) Some experiments that reflect effects under specific conditions of chronic elevated O-GlcNAcylation on cardiomyocyte, mitochondria, smooth muscle cell, and heart function. HDAC4, histone deacetylase 4; NF-κβ/p65, nuclear transcription factor kappa-beta-p65; LPS, lipopolysaccharide; GlcN, Glucosamine; OGT, O-linked N-Acetylglucosamine transferase; TNF-α, tumor necrosis factor-α; iNOS, inducible nitric oxide synthase; O-GlcNAc, O-linked β-N-acetylglucosamine; DRP1, dynamin-related protein 1; A20, also known as TNFAIP3 tumor necrosis factor α-induced protein 3. For more detail see the text.