Fig. 8. In vivo anti-tumor effect of complex 1a (25 mg kg−1) and cisplatin (1.5 mg kg−1) in a nude mouse model bearing NCI-H460 lung cancer xenografts. (a) Tumor volume and (b) body weight of mice (n = 6). (c) Weight and (d) photograph of the dissected tumors harvested from mice after 14 days of treatment. Data are expressed as the mean ± standard error; **p < 0.01. (e) H&E stained images of major organs harvested from mice after 14 days of treatment; scale bar = 50 μm. (f) Blood biochemistry analysis of alanine aminotransferase (ALT; upper) and creatinine (lower) in different groups of mice after 14 days of treatment. (g) H&E (left) and Ki-67 antigen (right) stained images of tumor tissues from mice after 14 days of treatment; scale bar = 50 μm. The yellow arrows indicate the nuclear fragmentation as shown in the enlarged area. (h) Representative TEM images of the ultrastructure of NCI-H460 tumors harvested from 1a-treated mice.
