TABLE 3.

Conditional Growth Model With Random Intercept and Slope of Time

	Coefficient Estimate	Standard Error	t Statistic	P *
(Intercept)	−0.024	0.446	−0.053	0.958
Time in years	−0.218	0.029	−7.457	<0.001
Medication adherence (0% to 100% interval)	−0.358	0.113	−3.160	0.002
Disease severity at baseline†
Mild (≥−2 dB)	Reference
Moderate (−2.0 dB through <−6.0 dB)	−2.124	0.147	−14.424	<0.001
Severe (−6.0 dB through <−12.0 dB)	−5.577	0.172	−32.363	<0.001
Very severe (<−12.0 dB)	−13.333	0.205	−65.059	<0.001
Missing baseline disease severity	−3.782	0.154	−24.508	<0.001
Age in years at initiation of medication
Below 40	Reference
40 to below 60	0.168	0.426	0.394	0.694
60 to below 80	−0.369	0.423	−0.873	0.383
80 or above	−1.245	0.451	−2.758	0.006
Patient sex
Female	Reference
Male	−0.427	0.092	−4.632	<0.001
Race/ethnicity
White, non-Hispanic	Reference
Black, non-Hispanic	−0.385	0.126	−3.051	0.002
Hispanic	−0.301	0.121	−2.482	0.013
Asian, non-Hispanic	−0.332	0.143	−2.315	0.021
Other, non-Hispanic	−0.273	0.398	−0.686	0.493
History of diabetic retinopathy	−0.303	0.210	−1.447	0.148
History of stroke	−0.209	0.110	−1.903	0.057
Interaction of follow-up time and medication adherence	0.061	0.022	2.739	0.006
Interaction of follow-up time and moderately severe disease at baseline	−0.140	0.030	−4.613	<0.001
Interaction of follow-up time and severe disease at baseline	−0.315	0.036	−8.847	<0.001
Interaction of follow-up time and very severe disease at baseline	−0.264	0.044	−5.972	<0.001
Interaction of follow-up time and missing baseline disease severity	−0.054	0.030	−1.789	0.074

^*Modeling was performed using a conditional growth model and the Wald test was used to test the regression coefficients.

^†Glaucoma severity is based on mean deviation in visual field closest to and within ±6 months of initiation of medication. Glaucoma severity is a clustering effect, not a covariate.

dB indicates decibel.