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. 2021 Nov 30;219(1):e20212207. doi: 10.1084/jem.20212207

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© 2021 Tait Wojno

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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graphic file with name JEM_20212207_Fig2.jpg — Helminth regulation of the host intestinal epithelium: A cost–benefit analysis. H. polygyrus produces HpES that modulates the host small intestinal epithelium in mice. HpES acts on intestinal stem cells (ISCs) to suppress tuft cell hyperplasia and cause the emergence of a fetal-like state. This modulation has potential costs and benefits for both host and parasite.