|
Total
|
113 (100%) |
30 (27%) |
32 (28%) |
20 (18%) |
31 (100%) |
|
Demographics
|
|
|
|
|
|
| Age (years), mean (SD) |
48.58 (12.53) |
56.77 (10.2) |
53.25 (10.4) |
43.25 (10.5) |
39.29 (10.28) |
| Male |
58 (51.3%) |
23 (76.7%) |
18 (56.2%) |
7 (35.0%) |
10 (32.3%) |
| Female |
55 (48.7%) |
7 (23.3%) |
14 (43.8%) |
13 (65.0%) |
21 (67.7%) |
| BMI categories
|
|
|
|
|
|
| Normal |
28 (24.8%) |
3 (10%) |
3 (9.4%) |
9 (45%) |
13 (41.9%) |
| Overweight |
43 (38.1%) |
12 (40%) |
12 (37.5%) |
6 (30%) |
13 (41.9%) |
| Obese |
42 (37.2%) |
15 (50%) |
17 (53.1%) |
5 (25%) |
5 (16.1%) |
|
Comorbidities
|
|
|
|
|
|
| Cardiovascular disease |
9 (8%) |
7 (23.3%) |
2 (6.2%) |
0 (0%) |
- |
| Hypertension |
37 (32.7%) |
19 (63.3%) |
17 (53.1%) |
1 (5%) |
- |
| Chronic pulmonary disease (asthma, COPD) |
4 (3.5%) |
2 (6.7%) |
2 (6.2%) |
0 (0%) |
- |
| Dyslipidemia |
3 (2.7%) |
1 (3.3%) |
2 (6.2%) |
0 (0%) |
- |
| Diabetes mellitus |
14 (12.4%) |
7 (23.3%) |
7 (21.9%) |
0 (0%) |
- |
| History of smoking |
7 (6.2%) |
4 (13.3%) |
2 (6.2%) |
1 (5%) |
- |
|
COVID symptoms at presentation
|
|
|
|
|
- |
| Cough |
57 (50.4%) |
21 (70%) |
25 (78.1%) |
11 (55%) |
- |
| Shortness of breath |
22 (19.5%) |
8 (26.7%) |
11 (34.4%) |
3 (15%) |
- |
| Dyspnea |
33 (29.2%) |
19 (63.3%) |
13 (40.6%) |
1 (5%) |
- |
| Fever |
48 (42.5%) |
19 (63.3%) |
19 (59.4%) |
10 (50%) |
- |
| Myalgia |
33 (29.2%) |
12 (40%) |
15 (46.9%) |
6 (30%) |
- |
| Odinophagy |
23 (20.4%) |
11 (36.7%) |
4 (12.5%) |
8 (40%) |
- |
| Rhinorrhea |
14 (12.4%) |
2 (6.7%) |
6 (18.8%) |
6 (30%) |
- |
| Diarrhea |
12 (10.6%) |
7 (23.3%) |
3 (9.4%) |
2 (10%) |
- |
| Vomit |
3 (2.7%) |
2 (6.7%) |
1 (3.1%) |
- |
- |
| Ageusia |
10 (8.8%) |
5 (16.7%) |
4 (12.5%) |
1 (5%) |
- |
| Anosmia |
11 (9.7%) |
5 (16.7%) |
5 (15.6%) |
1 (5%) |
- |
| Asthenia |
35 (31%) |
16 (53.3%) |
15 (46.9%) |
4 (20%) |
- |
|
Vital signs and laboratory measures
|
|
|
|
|
- |
| Oxygen saturation > 95% |
67 (59.3%) |
1 (3.3%) |
15 (46.9%) |
- |
- |
| D-dimer, mean (SD) |
3.92 (19.89) |
1.98 (5.44) |
0.75 (0.47) |
36.49 (72.34) |
- |
| Creatinine, mean (SD) |
0.94 (0.35) |
1.04 (0.48) |
0.87 (0.2) |
0.87 (0.15) |
- |
| Urea, mean (SD) |
36.8 (17.15) |
43.55 (22.55) |
32.43 (10.01) |
30.11 (6.85) |
- |
| C-reactive protein, mean (SD) |
63.7 (88.1) |
142.67 (99.14) |
75.72 (77.87) |
6.02 (4.21) |
2.77 (3.87) |
| Chest CT category (Ground Glass Opacities)
|
|
|
|
|
- |
| 0 –no GG opacities |
2 (1.8%) |
0 (0%) |
0 (0%) |
2 (15.4%) |
- |
| I–up to 25% |
32 (28.3%) |
3 (10%) |
18 (56.2%) |
11 (84.6%) |
- |
| II– 25%–50% |
23 (20.4%) |
12 (40%) |
11 (34.4%) |
- |
- |
| III–> 50% |
18 (15.9%) |
15 (50%) |
3 (9.4%) |
- |
- |
|
Metabolite and ratio measures, mean (SD)
|
|
|
|
|
|
| IDO (Kyn/Trp) |
0.07 (0.07) |
0.12 (0.1) |
0.06 (0.03) |
0.03 (0.01) |
- |
| (Cit/Orn) |
0.24 (0.11) |
0.21 (0.08) |
0.21 (0.09) |
0.35 (0.12) |
- |
| [(Kyn/Trp)/(Cit/Orn)] |
0.39 (0.37) |
0.6 (0.47) |
0.36 (0.25) |
0.11 (0.08) |
- |
| (IDO/lysoPC a C18:0) |
0.0027 (0.0038) |
0.0046 (0.0056) |
0.0020 (0.0014) |
0.00092 (0.00080) |
- |
| (Glu/PC aa C34:3) |
11 (9.28) |
14.93 (10.36) |
11.24 (8.54) |
4.73 (4.27) |
- |
| (Asp/PC aa C34:3) |
0.75 (0.56) |
0.92 (0.46) |
0.81 (0.68) |
0.39 (0.31) |
- |
| (IDO/PC aa C34:3) |
0.01 (0.01) |
0.01 (0.01) |
0.01 (0) |
0 (0) |
- |
| C5 |
0.38 (0.31) |
0.5 (0.39) |
0.36 (0.24) |
0.24 (0.18) |
- |
|
COVID-19-related Outcomes
|
|
|
|
|
|
| Recovered/discharged |
77 (68.1%) |
25 (83.3%) |
32 (100%) |
20 |
- |
| Required oxygen mask |
18 (15.9%) |
15 (50%) |
18 (15.9%) |
- |
- |
| OTI + Mechanical Ventilation |
18 (15.9%) |
18 (60%) |
18 (15.9%) |
- |
- |
| Tracheostomy |
7 (6.2%) |
7 (23.3%) |
7 (6.2%) |
- |
- |
| Death |
5 (4.4%) |
5 (16.7%) |
5 (4.4%) |
- |
0 (0%) |
