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. 2021 Dec 1;16(12):e0260864. doi: 10.1371/journal.pone.0260864

Fig 1. SFRP2 is downregulated in radiotherapy treated glioma patients and predicted poor prognosis.

Fig 1

A, the differentially expressed mRNAs in radiotherapy-treated glioma patients versus non-radiotherapy treated glioma patients in TCGA were depicted in the volcano plots. B, SFRP2 expression in radiotherapy-treated glioma patients and non-radiotherapy treated glioma patients in TCGA. C, SFRP2 expression in WHO grade II, III and IV glioma patients in TCGA. D, overall survival of glioma patients according to SFRP2 expression in TCGA. E, progression-free survival of glioma patients according to SFRP2 expression in TCGA. F, SFRP2 expression in radiotherapy-treated glioma patients and non-radiotherapy treated glioma patients in the validated cohort of our study. G, SFRP2 expression in WHO grade II, III and IV glioma patients in the validated cohort of our study. H, overall survival of glioma patients according to SFRP2 expression in the validated cohort of our study. I, progression-free survival of glioma patients according to SFRP2 expression in the validated cohort of our study. J, IHC staining of SFRP2 in radiotherapy-treated glioma tissue and non-radiotherapy treated glioma tissue. K, SFRP2 expression in glioma cell lines or normal glia tissue was evaluated by qRT-PCR. **P< 0.001.