Table 1. Parameter values for Schistosoma haematobium used in making acquired immunity model predictions of MDA impact (some directly estimated from age-intensity or prevalence profiles and some derived from the literature).
The value in square brackets indicate the 95% Credible Intervals.
| Parameter | Value | Source |
|---|---|---|
| Population size | 500 | - |
| Fecundity | 3.6 eggs/female/sample | [37,38] |
| Basic reproduction number | R0 = 2.55 [2.1–2.8] | Fitted |
| Level of aggregation of parasites in host population | Negative binomial, k = 0.24 | [35] |
| Adult worm life expectancy | 4 years | [20,31] |
| Praziquantel drug efficacy | 99% | [38,39] |
| Protective strength (δ) | 0.002 | [19,32] |
| Decay rate of acquired immunity (θ) | 0.2 | [19,32] |
| Age specific contact rates (β). | For 0–4,5–11,12–22,23+ years of age: 0.18 [0.13–0.20],1,0.14 [0.03–0.18], 0.037[0.028–0.043] |
Fitted |
| Contribution to the reservoir by contact age group (ρ). | For 0–4,5–11,12–22,23+ years of age: 0.18 [0.13–0.20],1,0.14 [0.03–0.18], 0.037[0.028–0.043] |
Fitted |
| Prevalence of infection | Percentage of population having >0 eggs/10ml | - |
| Heavy-intensity infection prevalence | Percentage of population having ≥50 eggs/10ml | [1,40] |
| Human demography | Based on Kenya’s demographic profile | - |