Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 1;7(49):eabl3857. doi: 10.1126/sciadv.abl3857

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 2. — (A and B) 5-HT interactions within the central binding site for the outward (A) and occluded (B) conformations. Hydrogen bonds formed between 5-HT and D98 and T439 are indicated with dark blue dashed lines. (C) Chemical structures of 5-HT and methyl analogs, with the methyl groups circled. (D) Comparison of 5-HT binding pose and interactions with surrounding residues in the allosteric site in the outward (purple) and occluded (gray) conformations. (E) Comparison of 5-HT binding in the allosteric site with S-citalopram binding in the extracellular vestibule (PDB code: 5I73, gray). (F) Plots of competition binding of 5-HT (black circles) and the N-indole methyl derivative (orange squares) against [³H]VLZ in NaCl. Data are means ± SEM.