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. 2021 Dec 1;7(49):eabk0172. doi: 10.1126/sciadv.abk0172

Fig. 3. Sensitivity of SARS-CoV-2 variants B.1, B.1.1.7 (Alpha), B.1.351 (Beta), B.1.128.1 (Gamma), and B.1.617.2 (Delta) to neutralization by antibodies in sera of sCPD9-vaccinated Roborovski dwarf hamsters.

Fig. 3.

(A) Neutralizing antibody titers of hamster sera collected on days 2 and 3 after challenge. Geometric mean and SD of the respective group titers are shown. The Kruskal-Wallis test with Dunn’s post hoc test showed that hamster sera neutralized the virus variants B.1.351, B.1.128.1, and B.1.617.2 significantly less efficiently than variants B.1 or B.1.1.7 (*P = 0.0264, **P = 0.0012, *** P < 0.001, and ****P < 0.0001). (B) Titers of neutralizing antibodies are plotted as a function of challenge virus. (C) Ratios of serum neutralization titers against different virus variants. The ratios show to which extent each hamster serum neutralizes different virus variants. The ratios of the neutralization titers of individual sera, the geometric mean, and the SD are shown. The geometric mean is also displayed as a number in the upper part of the diagram.