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. 2021 Dec 1;7(49):eabj1215. doi: 10.1126/sciadv.abj1215

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Fig. 4. — (A) Schematics and representative traces of mEPSC and EPSC recordings in the indicated genotypes performed in standard or modified (Cl⁻ free) saline. Although vGlut-OE increases mEPSC amplitude in both saline conditions, no change in presynaptic neurotransmitter release is observed in vGlut-OE NMJs recorded in Cl⁻-free saline, leading to enhanced EPSC amplitude and a failure to express PHD. (B to D) Quantification of average mEPSC amplitude (B), EPSC amplitude (C), and quantal content values (D) for the indicated genotypes and conditions (wild type, n = 15; vGlut-OE, n = 17; wild type Cl⁻ free, n = 12; vGlut-OE Cl⁻ free, n = 13). **P < 0.01 and ***P < 0.001. (E) Quantification of mEPSC and quantal content values normalized to baseline values (−vGlut-OE) for wild-type NMJs in standard or Cl⁻ -free saline. ***P < 0.001.