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. 2021 Dec;2(12):e811–e819. doi: 10.1016/S2666-7568(21)00253-1

Figure 5.

Figure 5

Antibody titres of individuals with reinfection over time

(A) Live virus 50% reduction in neutralising antibody measured by Focus reduction (FRNT50) to England.2 virus. (B) Live virus FRNT50 to alpha (B.1.1.7). (C) RBD specific IgG titres over time for the 10 individuals with confirmed reinfection (identification numbers correspond to table 1). (D) Correlation between live virus FRNT50 to England.2 virus and live virus FRNT50 to alpha (B.1.1.7) virus. Statistical analysis using Spearman's rank correlation coefficient (r). X axes refer to timepoints of serological sampling in figures A–C. A minimum of two samples were available for nine individuals with the first sample in May or June, 2020 (at T1), and second sample in September or October (at T2). One individual only had one sample available before reinfection. Samples 1 and 2 represent samples taken from individuals before reinfection (T1 or T2) and samples 3 and 4 represent samples taken after reinfection. Post-reinfection serological samples were available for nine individuals who had a sample within 7–14 days of reinfection RT-PCR (sample 3); an additional five had a further sample (sample 4) taken 4–6 weeks after reinfection RT-PCR. RBD=receptor binding domain assay. FRNT50=focus reduction neutralisation test with 50% reduction of the virus control.