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The intracellular mechanisms related to astrocyte activation. After ischemic stroke, different types of cells promote astrocyte activation by secreting various factors, including activated microglia, dead neurons, endothelial cells, and other cells. These factors act by entering the cell via multiple pathways, such as the JAK/STAT3 pathway, the Olig2 pathway, TGF-β/The Smad pathway, and other pathways.
