Table 2.
T cell receptors specific to islet epitopes.
| Clone/Sequence ID | Epitope | Epitope sequence | HLA# | TRAV | TRAJ | CDR3a | TRBV | TRBJ | CDR3b | Source of T cells | Method to confirm reactivity | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BRI4.13 | GAD65:555-567 | NFFRMVISNPAAT | DR4 | TRAV19 | TRAJ44 | CALSENRGGTASKLTF | TRBV5-1 | TRBJ1-1 | CASSLVGGPSSEAFF | PBMC CD4 | Clone/Transgenic cells | (79–81) |
| BRI164 | GAD65:555-567 | NFFRMVISNPAAT | DR4 | TRAV19 | TRAJ56 | CALSEEGGGANSKLTF | TRBV5-1 | TRBJ1-6 | CASSLAGGANSPLHF | PBMC CD4 | Clone/Transgenic cells | (80, 82) |
| T1D2-1&2 | IGRP:305-324 | QLYHFLQIPTHEEHLFYVLS | DR4 | TRAV29 | TRAJ40 | CAATRTSGTYKYIF | TRBV6-6 | TRBJ2-3 | CASSPWGAGGTDTQYF | PBMC CD4 | Clone/TCR transductant | (81) |
| T1D4-3&4 | IGRP:305-324 | KWCANPDWIHIDTTPFAGLV | DR4 | TRAV2 | TRAJ15 | CAVEDLNQAGTALIF | TRBV5-1 | TRBJ2-1 | CASSLALGQGNQQFF | PBMC CD4 | Clone/TCR transductant | (81) |
| 23.G8 | PPI:36-50 | VEALYLVCGERGFFY | DR4 | TRAV39 | TRAJ56 | CAWRTGANSKLTF | TRBV24-1 | TRBJ2-2 | CATGLAANTGELFF | Islet CD4 | TCR transductant | (83) |
| SD52.c1 | PPI:72-90 | PGAGSLQPLALEGSLQKRG | DR4 | TRAV4 | TRAJ27 | CLVGDSLNTNAGKSTF | TRBV27 | TRBJ1-5 | CASSWSSIGNQPQHF | PBMC CD4 | Clone | (82, 84) |
| 95.A9-1 | PPI:87-101 | QKRGIVEQCCTSICS | DR4.4 | TRAV9-2 | TRAJ18 | CALRTDRGSTLGRLYF | TRBV11-2 | TRBJ1-6 | CASSLQSSYNSPLHF | Islet CD4 | TCR transductant | (83) |
| Mi.1 | Insulin A:1-15 (PPI: 90-104) | GIVEQCCTSICSLYQ | DR4 | TRAV8-3 | TRAJ44 | CAVGALAGTASKLTF | TRBV29-1 | TRBJ2-3 | CSVEATRADTQYF | PLN CD4 | Clone | (85) |
| Ba.14 | Insulin A:1-15 (PPI: 90-104) | GIVEQCCTSICSLYQ | DR4 | TRAV39 | TRAJ33 | CAVVNMDSNYQLIW | TRBV5-1 | TRBJ2-3 | CASSLATSGGGSDTQYF | PLN CD4 | Clone | (85) |
| Ba.11 | Insulin A:1-15 (PPI: 90-104) | GIVEQCCTSICSLYQ | DR4 | TRAV22 TRAV26-2 ## |
TRAJ52 TRAJ47 |
CADAGGTSYKLF CIPGSEEYGNKLVF |
TRBV5-1 | TRBJ2-3 | CASSLATSGGGSDTQYF | PLN CD4 | Clone | (85) |
| 6.H11 | PPI:94-108 | QCCTSICSLYQLENY | DR4.2 | TRAV26-1 | TRAJ13 | CIVRVYSGGYQKVTF | TRBV30 | TRBJ2-3 | CAWSARLAGGPRTQYF | Islet CD4 | TCR transductant | (83) |
| SD32.5 | PPI:94-110 | QCCTSICSLYQLENYCN | DR4 | TRAV26-1 | TRAJ23 | CIVRVSSAYYNQGGKLIF | TRBV27 | TRBJ2-3 | CASSPRANTDTQYF | PBMC CD4 | Clone | (82, 84) |
| B3.3 | Proinsulin:52-62 (PPI:76-86) | SLQPLALEGSL | DR4 | TRAV17 | TRAJ54 | CATGPIQGAQKLVF | TRBV6-5 | TRBJ1-1 | CASSYAWGRATEAFF | PBMC CD4 | Clone | (86) |
| K4.4/K6.4 | Proinsulin:54-63 (PPI:78-87) | QPLALEGSLQ | DR4 | TRAV10 | TRAJ17 | CVVSAKAAGNKLTF | TRBV7-8 | TRBJ2-7 | CASSLAGTDHYEQYF | PBMC CD4 | Clone | (86) |
| 23.F7 | PPI:24-38 | AFVNQHLCGSHLVEA | DR1 | TRAV8-2 | TRAJ29 | CAVIASGNTPLVF | TRBV19 | TRBJ2-3 | CASKGPGTVIRADTQYF | Islet CD4 | TCR transductant | (83) |
| 55.B3 | PPI:37-51 | EALYLVCGERGFFYT | DR9 | TRAV21 | TRAJ29 | CAVLPPTPLVF | TRBV18 | TRBJ1-1 | CASSYPGTGGARTEAFF | Islet CD4 | TCR transductant | (83) |
| 55.C10 | PPI:58-72 | AEDLQVGQVELGGGP | DR53 | TRAV26-1 | TRAJ26 | CIVRSHGQNFVF | TRBV20-1 | TRBJ2-7 | CSARPGTRNYEQYF | Islet CD4 | TCR transductant | (83) |
| Clone 5 | Insulin B:9-23 (PPI: 33-47) | SHLVEALYLVCGERG | DQ8 | TRAV21 | TRAJ6 | CAVKRTGGSYIPTF | TRBV11-2 | TRBJ2-2 | CASSSFWGSDTGELFF | PBMC CD4 | Clone/TCR transductant | (82, 87, 88) |
| GSE.6H9 | Insulin B:9-23 (PPI: 33-47) | SHLVEALYLVCGERG | DQ8, DQ8-trans | TRAV26-1 | TRAJ40 | CIVRVDSGTYKYIF | TRBV7-2 | TRBJ2-1 | CASSLTAGLASTYNEQFF | Islet CD4 | TCR transductant | (73, 83) |
| GSE.20D11 | Insulin B:9-23 (PPI: 33-47) | SHLVEALYLVCGERG | DQ8 | TRAV12-3 | TRAJ4 | CAILSGGYNKLIF | TRBV2 | TRBJ2-5 | CASSAETQYF | Islet CD4 | TCR transductant | (73, 83) |
| T1D#3 C8 | Insulin B:11-23 (PPI: 35-47)R22E | LVEALYLVCGEEG | DQ8 | TRAV17 | TRAJ23 | CATDAGYNQGGKLIF | TRBV5-1 | TBBJ1-3 | CASSAGNTIYF | PBMC CD4 | Clone | (82, 89) |
| T1D#3 C10 | Insulin B:11-23 (PPI: 35-47)R22E | LVEALYLVCGEEG | DQ8 | TRAV12-3 | TRAJ26 | CATAYGQNFVF | TRBV4-1 | TRBJ2-2 | CASSRGGGNTGELFF | PBMC CD4 | Clone | (82, 89) |
| 19.A4 | PPI:55-69 | RREAEDLQVGQVELG | DQ8 | TRAV8-6 | TRAJ32 | CAVRETGATNKLIF | TRBV20-1 | TRBJ2-7 | CSARPQGFSSYEQYF | Islet CD4 | TCR transductant | (83) |
| GSE.8E3 | PPI:72-87 hEL:C-peptide (HIP11) |
PGAGSLQPLALEGSLQ SLQPLALEAEDLQV |
DQ8, DQ8-trans | TRAV2 | TRAJ37 | CAVDGSGNTGKLIF | TRBV4-1 | TRBJ2-7 | CASSQDLAGVREQYF | Islet CD4 | TCR transductant | (73, 83) |
| 6.G4 | PPI:86-100 | LQKRGIVEQCCTSIC | DQ8, DQ8-trans | TRAV26-1 | TRAJ8 | CIVRVRNTGFQKLVF | TRBV27 | TRBJ1-1 | CASSPGPGNTEAFF | Islet CD4 | TCR transductant | (83) |
| 56.B1 | PPI:40-54 | YLVCGERGFFYTPKT | DQ2 | TRAV13-1 | TRAJ40 | CAVLSPSGTYKYIF | TRBV7-9 | TRBJ1-4 | CASSLMGNPHEKLFF | Islet CD4 | TCR transductant | (83) |
| 53.A4-1 | PPI:72-87 | PGAGSLQPLALEGSLQ | DQ2 | TRAV39 | TRAJ33 | CAVDPMDSNYQLIW | TRBV29-1 | TRBJ2-6 | CSVGTDPSGANVLTF | Islet CD4 | TCR transductant | (83) |
| 23.G6 | PPI:29-43 | HLCGSHLVEALYLVC | DP4 | TRAV9-2 | TRAJ6 | CALSISGGSYIPTF | TRBV5-1 | TRBJ2-5 | CASSFRQGEQETQYF | Islet CD4 | TCR transductant | (83, 90) |
| A4.13 | Proinsulin:41-51 (PPI:65-75) | QVELGGGPGAG | DQ8 | TRAV6 | TRAJ36 | CALKYGANNLFF | TRBV18 | TRBJ1-1 | CASSPTTGGDEAFF | Islet CD4 | Clone | (70) |
| A1.1 | Proinsulin:50-59 (PPI:74-83) | AGSLQPLALE | DQ8 | TRAV25 | TRAJ16 | CAGGFSDGQKLLF | TRBV20-1 | TRBJ2-7 | CSARTEAYEQYF | Islet CD4 | Clone | (70) |
| A1.2 | Proinsulin:50-58 (PPI:74-82) | AGSLQPLAL | DQ8 | TRAV20 | TRAJ58 | CAVIETSGSRLTF | TRBV20-1 | TRBJ2-3 | CSARDQQRVDTQYF | Islet CD4 | Clone | (70) |
| A2.4 | Proinsulin:52-62 (PPI:76-86) | SLQPLALEGSL | DQ8-trans | TRAV19 | TRAJ49 | CALSRAGTGNQFYF | TRBV5-1 | TRBJ2-4 | CASSLGLRGENIQYF | Islet CD4 | Clone | (70) |
| B3.1 | Proinsulin:48-59 (PPI:72-83) | PGAGSLQPLALE | DQ8 | TRAV12-1 | TRAJ9 | CVVKSTGGFKTIF | TRBV20-1 | TRBJ2-5 | CSAGGLAGASQETQYF | PBMC CD4 | Clone | (86) |
| K3.2/K9.5 | Proinsulin:54-62 (PPI:78-86) | QPLALEGSL | DQ2 | TRAV3 | TRAJ31 | CAVRGDNNARLMF | TRBV7-2 | TRBJ2-2 | CASSPIIWGTGELFF | PBMC CD4 | Clone | (86) |
| K6.2 | Proinsulin:49-58 (PPI:73-82) | GAGSLQPLAL | DQ8-trans | TRAV8-2/8-4 | TRAJ11 | CAVTPKSGYSTLTF | TRBV20-1 | TRBJ2-3 | CSARDLAIPDTQYF | PBMC CD4 | Clone | (86) |
| K9.6 | Proinsulin:41-51 (PPI:65-75) | QVELGGGPGAG | DQ8 | TRAV26-1 | TRAJ54 | CIVRVEIQGAQKLVF | TRBV3-2 | TRBJ2-1 | CASSSPGTEYNEQFF | PBMC CD4 | Clone | (86) |
| D1.1/D1.4 | Proinsulin:34-43 (PPI:58-67) | AEDLQVGQVE | DQ8 | TRAV13-1 | TRAJ38 | CAARNAGNNRKLIW | TRBV4-2 | TRBJ2-3 | CASSFRGLGGGTDTQYF | PBMC CD4 | Clone | (86) |
| T6.1 | Proinsulin:52-63 (PPI:76-87) | SLQPLALEGSLQ | DQ2, DQ2-trans | Functional alpha not detected | TRBV9 | TRBJ2-1 | CASSVDPGVYNEQFF | PBMC CD4 | Clone | (86) | ||
| T6.6 | Proinsulin:56-62 (PPI:80-86) | LALEGSL | DQ2 | TRAV35 | TRAJ28 | CAAALSGAGSYQLTF | TRBV19 | TRBJ2-3 | CASRLDPSTDTQYF | PBMC CD4 | Clone | (86) |
| T17.1 | Proinsulin:56-62 (PPI:80-86) | LALEGSL | DQ2, DQ2-trans | TRAV35 | TRAJ28 | CAAALSGAGSYQLTF | TRBV19 | TRBJ2-3 | CASRLDPSTDTQYF | PBMC CD4 | Clone | (86) |
| H3.3/H6.4 | Proinsulin:52-61 (PPI:76-85) | SLQPLALEGS | DQ8-trans | TRAV19 | TRAJ57 | CALSGRGSEKLVF | TRBV5-1 | TRBJ2-7 | CASSTRTGQGGNEQYF | PBMC CD4 | Clone | (86) |
| H3.7/H7.4/H8.5 | Proinsulin:50-58 (PPI:74-82) | AGSLQPLAL | DQ8 | TRAV12-1 | TRAJ20 | CVVNPTDDYKLSF | TRBV20-1 | TRBJ2-3 | CSARSLASGGPDTQYF | PBMC CD4 | Clone | (86) |
| H11.5 | Proinsulin:42-51 (PPI:66-75) | VELGGGPGAG | DQ8 | TRAV26-1 | TRAJ36 | CIVRVVTGANNLFF | TRBV5-1 | TRBJ2-5 | CASSLERETQYF | PBMC CD4 | Clone | (86) |
| E2.3 | Proinsulin:54-62 (PPI:78-86) | QPLALEGSL | DQ2 | TRAV30 | TRAJ37 | CGTEKPGSGNTGKLIF | TRBV20-1 | TRBJ1-4 | CSARDGARGEKLFF | PBMC CD4 | Clone | (86) |
| E2.5 | Proinsulin:35-46 (PPI:59-70) | EDLQVGQVELGG | DQ8 | TRAV12-3 | TRAJ5 | CVISPPGRRALTF | TRBV5-4 | TRBJ2-2 | CASSSGTSAGTGELFF | PBMC CD4 | Clone | (86) |
| A3.10 | hEGGG : IAPP2 (HIP6) | GQVELGGGNAVEVLK | DQ8 | TRAV38-1 | TRAJ54 | CAFFGQGAGKLVF | TRBV5-1 | TRBJ2-3 | CASSLSASGGATDTQYF | Islet CD4 | Clone | (70, 91, 92) |
| A1.9 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) |
VELGGGPGA GQVELGGGNAVEVLK |
DQ8 | TRAV20 | TRAJ7 | CAVQAGGNNRLAF | TRBV5-1 | TRBJ1-2 | CASSLERDGYTF | Islet CD4 | Clone | (70, 92) |
| A6.15/A5.8 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) |
VELGGGPGA GQVELGGGNAVEVLK |
DQ8 | TRAV26-1 | TRAJ21 | CIAIYNFNKFYF | TRBV5-1 | TRBJ1-6 | CASSLEASSYNSPLHF | Islet CD4 | Clone | (70, 92) |
| A2.13 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) |
VELGGGPGA GQVELGGGNAVEVLK |
DQ8 | TRAV26-1 | TRAJ39 | CIVSHNAGNMLTF | TRBV5-1 | TRBJ2-5 | CASSLERETQYF | Islet CD4 | Clone | (70, 92) |
| A5.5 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) |
VELGGGPGA GQVELGGGNAVEVLK |
DQ8 | TRAV26-1 | TRAJ54 | CIVRVEIQGAQKLVF | TRBV5-1 | TRBJ2-5 | CASSLGPGQRETQYF | Islet CD4 | Clone | (70, 92) |
| A2.11 | hEGGG : IAPP2 (HIP6) | GQVELGGGNAVEVLK | Not reported | TRAV38-1 | TRAJ54 | CAFMGAGAQKLVF | TRBV4-3 | TRBJ2-3 | CASSQILRGGPPDTQYF | Islet CD4 | Clone | (70, 91) |
| HIP14-G10/D3 | hEL : IAPP2 (HIP14) | SLQPLALNAVEVLK | DR | TRAV16 TRAV5 ## |
TRAJ37 TRAJ40 |
CARSHGSGNTGKLIF CAESIASGTYKYIF |
TRBV27 | TRBJ2-5 | CASSSGYGGETQYF | PBMC CD4 | Clone | (93) |
| E2b | hEL:C-peptide (HIP11) | SLQPLALEAEDLQV | DQ2 | TRAV8-4 | TRAJ43 | CAVGATNNNDMRF | TRBV5-4 | TRBJ2-1 | CASSPIGASGGNEQFF | PBMC CD4 | Clone | (94) |
| ET650-2 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) HIPL11C |
VELGGGPGA GQVELGGGNAVEVLK GQVELGGGNAVEVCK |
DQ8 | TRAV26-1 | TRAJ39 | CIVRVGYNAGNMLTF | TRBV20-1 | TRBJ1-5 | CSAIAGPNQPQHF | PBMC CD4 | Clone | (92) |
| ET650-4 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) HIPL11C |
VELGGGPGA GQVELGGGNAVEVLK GQVELGGGNAVEVCK |
DQ8 | TRAV26-1 | TRAJ42 | CIVRVAIEGSQGNLIF | TRBV5-1 | TRBJ1-3 | CASSLRRGDTIYF | PBMC CD4 | Clone | (92) |
| ET650-5 | hEGGG : IAPP2 (HIP6) HIPL11C |
GQVELGGGNAVEVLK GQVELGGGNAVEVCK |
DQ8 | TRAV26-1 | TRAJ9 | CIVRLQSGGFKTIF | TRBV20-1 | TRBJ1-2 | CSAYSPGDRDFSNYGYTF | PBMC CD4 | Clone | (92) |
| ET672-1 | Proinsulin:42-50 (PPI:66-74) hEGGG : IAPP2 (HIP6) HIPL11C |
VELGGGPGA GQVELGGGNAVEVLK GQVELGGGNAVEVCK |
DQ8 | TRAV12-2 | TRAJ48 | CAVNHGNEKLTF | TRBV18 | TRBJ1-1 | CASSPWEGRMDTEAFF | PBMC CD4 | Clone | (92) |
| 1E6 | PPI:15-24 | ALWGPDPAAA | A*02:01 | TRAV12-3 | TRAJ12 | CAMRGDSSYKLIF | TRBV12-4 | TRBJ2-4 | CASSLWEKLAKNIQYF | PBMC CD8 | Clone | (82, 95) |
| 1D5/1D10/2B3/4C6/3E7 | PPI:3-11 | LWMRLLPLL | A*24:02 | TRAV5 | TRAJ37 | CAEPSGNTGKLIF | TRBV7–9 | TRBJ2-7 | CASSLHHEQYF | PBMC CD8 | Clone | (96) |
| Clone 7 | IGRP:265-273 | VLFGLGFAI | A*02:01 | TRAV41 | TRAJ48 | CAVTSNFGNEKLTF | TRBV6-2/6-3 | TRBJ2-7 | CASSSRFVGEGLFRYGYEQYF | PBMC CD8 | Clone/Transgenic cells | (97, 98) |
| Clone 32 | IGRP:265-273 | VLFGLGFAI | A*02:01 | TRAV12-1 | TRAJ48 | CVVNILSNFGNEKLTF | TRBV20-1 | TRBJ2-1 | CSASRQGWVNEQFF | PBMC CD8 | Clone/Transgenic cells | (97, 98) |
| Clone 16/17 | IGRP:265-273 | VLFGLGFAI | A*02:01 | TRAV25 | TRAJ53 | CAGLGDSGGSNYKLTF | TRBV3-1 | TRBJ2-4 | CASSQDRWDVMSKNIQYF | PBMC CD8 | Clone | (45) |
| Clone 22/27 | IGRP:265-273 | VLFGLGFAI | A*02:01 | TRAV29/DV5 | TRAJ53 | CAASGGSNYKLTF | TRBV10-3 | TRBJ1-2 | CAISDRFMREGMTYGYTF | PBMC CD8 | Clone | (45) |
| Clone#1 | INS-DRiP:1-9 | MLYQHLLPL | A*02:01 | TRAV12-2 | TRAJ34 | CAVNKTDKLIF | TRBV6-1 | TRBJ1-2 | CASSVTGNGYTF | PBMC CD8 | Clone | (99) |
| Clone#2 | INS-DRiP:1-9 | MLYQHLLPL | A*02:01 | TRAV10 | TRAJ8 | CVVNMNTGFQKLVF | TRBV12-3/12-4 | TRBJ2-2 | CASSPPQGGNTGELFF | PBMC CD8 | Clone | (99) |
| 1.C1 | INS-DRiP:1-9 | MLYQHLLPL | A*02:01 | TRAV12-1 | TRAJ39 | CGENNAGNMLTF | TRBV27 | TRBJ2-5 | CASSLQPPGTSTETQYF | Islet CD8 | TCR transductant | (74) |
| 96.A9 | INS-DRiP:1-9 | MLYQHLLPL | B*08:01 | TRAV12-2 | TRAJ39 | CAVNVYNAGNMLTF | TRBV30 | TRBJ1-1 | CAWSVRGGSYMNTEAFF | Islet CD8 | TCR transductant | (74) |
| D222D Clones 2 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV17 | TRAJ36 | CAVTGANNLFF | TRBV19 | TRBJ2-2 | CASSIEGPTGELF | PBMC CD8 | Clone | (7) |
| D010R clone 1E2 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV35 | TRAJ36 | CAGTRNNLFF | TRBV19 | TRBJ2-7 | CASGGSSYEQYF | PBMC CD8 | Clone | (7) |
| D010R clone 1D3 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV25 | TRAJ20 | CAGGSNDYKLSF | TRBV6-1 | TRBJ2-3 | CASSSVGVDTQYF | PBMC CD8 | Clone | (7) |
| D267T 33B8 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV19 | TRAJ23 | CALSEATYNQGGKLIF | TRBV19 | TRBJ1-3 | CASSIFPNPGNTIYF | PBMC CD8 | Clone | (7) |
| D349D 178B9 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV14/DV4 | TRAJ9 | CAMREGLTGGFKTIF | TRBV11-2 | TRBJ1-1 | CASSPFLTGSNTEAFF | PBMC CD8 | Clone | (7) |
| D351D 188D3 | ZNT8:186-194 | VAANIVLTV | A*02:01 | TRAV19 | TRAJ20 | CALSPAETSDYKLSF | TRBV19 | TRBJ1-1 | CASTLTGFAEAFF | PBMC CD8 | Clone | (7) |
| 23.F9 | PPI:1-11 | MALWMRLLPLL | C*03:04 | TRAV12-3 | TRAJ48 | CAMSALGNFGNEKLTF | TRBV19 | TRBJ2-1 | CASSIAGGNEQFF | Islet CD8 | TCR transductant | (74) |
| 19.A1 | PPI:1-11 | MALWMRLLPLL | C*03:04 | TRAV8-4 | TRAJ11 | CAVSDQGSGYSTLTF | TRBV28 | TRBJ1-5 | CASSWTANQPQHF | Islet CD8 | TCR transductant | (74) |
| 20.E5 | PPI:1-11 | MALWMRLLPLL | C*03:04 | TRAV14/DV4 | TRAJ52 | CAMSNAGGTSYGKLTF | TRBV28 | TRBJ1-4 | CASSLARYNEKLFF | Islet CD8 | TCR transductant | (74) |
| 20.F1 | PPI:1-11 | MALWMRLLPLL | C*03:04 | TRAV14/DV4 | TRAJ43 | CAMRLHNNNDMRF | TRBV28 | TRBJ1-5 | CASIASRYNQPQHF | Islet CD8 | TCR transductant | (74) |
| 22.A10 | PPI:1-11 | MALWMRLLPLL | C*03:04 | TRAV8-1 | TRAJ13 | CAVNAAGGYQKVTF | TRBV28 | TRBJ2-1 | CASIPDRYNEQFF | Islet CD8 | TCR transductant | (74) |
| 1.C8 | PPI:1-11/2-12/2-10 | MALWMRLLPLL ALWMRLLPLLA ALWMRLLPL |
A*02:01 | TRAV24 | TRAJ58 | CAFKRETSGSRLTF | TRBV13 | TRBJ2-1 | CASSTRLAGDEQFF | Islet CD8 | TCR transductant | (74) |
| 1.F3 | PPI:2-12 | ALWMRLLPLLA | A*02:01 | TRAV39 | TRAJ39 | CAVENAGNMLTF | TRBV10-2 | TRBJ2-1 | CASWTVSYNEQFF | Islet CD8 | TCR transductant | (74) |
| 96.F5 | PPI:3-11 | LWMRLLPLL | A*02:01 | TRAV8-6 | TRAJ48 | CAVSDISNFGNEKLTF | TRBV9 | TRBJ2-3 | CASSVVGLGTDTQYF | Islet CD8 | TCR transductant | (74) |
| 23.H5 | PPI:3-13 | LWMRLLPLLAL | A*02:01 | TRAV38-2/DV8 | TRAJ22 | CAYRSPARQLTF | TRBV6-1 | TRBJ2-7 | CASSEGWGVPSYEQYF | Islet CD8 | TCR transductant | (74) |
| 1.B10-1 | PPI:15-23 | ALWGPDPAA | A*02:01 | TRAV8-3 | TRAJ33 | CAVVADSNYQLIW | TRBV4-2/4-3 | TRBJ2-2 | CASSQTKGTGELFF | Islet CD8 | TCR transductant | (74) |
| 1.F1 | PPI:15-24 | ALWGPDPAAA | A*02:01 | TRAV39 | TRAJ41 | CAVSNSGYALNF | TRBV29-1 | TRBJ2-5 | CSVFHRGETQYF | Islet CD8 | TCR transductant | (74) |
| 23.C12 | PPI:15-24/15-25 | ALWGPDPAAA ALWGPDPAAAF |
A*02:01 | TRAV41 | TRAJ42 | CAVSGGSQGNLIF | TRBV28 | TRBJ1-2 | CASSPPTGWGGYTF | Islet CD8 | TCR transductant | (74) |
| 93.D1 | PPI:15-25 | ALWGPDPAAAF | A*02:01 | TRAV5 | TRAJ8 | CAVTKDTGFQKLVF | TRBV20-1 | TRBJ2-1 | CSARDHFGGSGYEQFF | Islet CD8 | TCR transductant | (74) |
| 10.C6-1 | PPI:23-32 | AAFVNQHLCG | C*12:03 | TRAV19 | TRAJ39 | CALSGALNNAGNMLTF | TRBV27 | TRBJ2-5 | CASSLFGYRQETQYF | Islet CD8 | TCR transductant | (74) |
| 28.D3 | PPI:31-41/34-41 | CGSHLVEALYL HLVEALYL |
A*02:01 | TRAV26-2 | TRAJ26 | CILTDNYGQNFVF | TRBV27 | TRBJ1-1 | CASSLIGLNTEAFF | Islet CD8 | TCR transductant | (74) |
| 28.E6 | PPI:46-54/47-54 | RGFFYTPKT GFFYTPKT |
A*29:02 | TRAV19 | TRAJ28 | CALSEAGAGSYQLTF | TRBV2 | TRBJ2-5 | CASSPSGTSSQETQYF | Islet CD8 | TCR transductant | (74) |
| 20.G1 | PPI:69-77/69-79 | GGGPGAGSL GGGPGAGSLQP |
C*03:04 | TRAV1-2 | TRAJ8 | CAVRMNTGFQKLVF | TRBV9 | TRBJ2-1 | CASSVGMDPGLGYNEQFF | Islet CD8 | TCR transductant | (74) |
| 96.B4 | PPI:91-99 | IVEQCCTSI | C*05:01 | TRAV12-2 | TRAJ31 | CAVNNARLMF | TRBV6-5 | TRBJ2-1 | CASRPTSGGYNEQFF | Islet CD8 | TCR transductant | (74) |
| 86.C1 | PPI:91-100/92-100/92-102 | IVEQCCTSIC VEQCCTSIC VEQCCTSICSL |
B*41:02 | TRAV19 | TRAJ16 | CALSEAGFSDGQKLLF | TRBV19 | TRBJ2-1 | CASSIQFSYNEQFF | Islet CD8 | TCR transductant | (74) |
| 84.D9 | PPI:91-100/92-100/92-102 | IVEQCCTSIC VEQCCTSIC VEQCCTSICSL |
B*41:02 | TRAV29/DV5 | TRAJ43 | CAASNSNDMRF | TRBV7-9 | TRBJ2-1 | CASSLAQREQFF | Islet CD8 | TCR transductant | (74) |
| 28.E11 | PPI:91-100 | IVEQCCTSIC | B*18:01 | TRAV12-2 | TRAJ49 | CAVSMNTGNQFYF | TRBV29-1 | TRBJ2-1 | CSVQVYNEQFF | Islet CD8 | TCR transductant | (74) |
| 1.E9-1 | PPI:92-99 | VEQCCTSI | B*50:01 | TRAV12-2 | TRAJ34 | CAVNIRYNTDKLIF | TRBV6-2/6-3 | TRBJ1-5 | CASSSIQGSGSGQPQHF | Islet CD8 | TCR transductant | (74) |
| 86.G3-2 | PPI:94-102 | QCCTSICSL | B*35:01 | TRAV8-6 | TRAJ33 | CAVSDGYQLIW | TRBV6-1 | TRBJ2-7 | CASSGREAPYEQYF | Islet CD8 | TCR transductant | (74) |
| 54.F1 | PPI:96-103 | CTSICSLY | A*01:01 | TRAV3 | TRAJ26 | CAVPDNYGQNFVF | TRBV7-2 | TRBJ2-2 | CASSLVVELFF | Islet CD8 | TCR transductant | (74) |
#HLA class II alleles: DR4 (DRB1*04:01); DR4.4 (DRB1*04:04); DR4.2 (DRB1*04:02); DR1 (DRB1*01:01); DR9 (DRB1*09:01); DR53 (DRB4*01:01); DQ8 (DQA1*03:01-DQB1*03:02); DQ8-trans (DQA1*05:01-DQB1*03:02); DQ2 (DQA1*05:01-DQB1*02:01/02:02), DQ2-trans (DQA1*03:01-DQB1*02:01); DP4 (DPA1*01:03-DPB1*04:01).
##Two in-frame alpha chains detected. Functional alpha not determined.