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. 2021 Nov 17;11:774937. doi: 10.3389/fonc.2021.774937

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Copyright © 2021 Wang, Si, Li, Li, Chen, Xue and Ren

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Risk of incident lung cancer according to genetic risk and the TyG index. Participants were divided into categories of low (quintile 1), intermediate (quintiles 2–4), and high (quintile 5) genetic risk strata. The TyG index was defined as low and high according to median level (TyG index = 8.639). The hazard ratios were estimated using Cox regression models after adjusting for age, sex, region, Townsend deprivation score, smoking status, alcohol intake frequency, body mass index, waist hip ratio, and hypertension, fasting time, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glycated hemoglobin as well as the top 10 principal components of the ancestry and genotyping array. TyG index, triglyceride-glucose index.