Table 1.
Baseline demographic and clinical characteristics in the study.
| Characteristics | Level | No Lung Cancer (n = 322741) | Lung Cancer (n = 1593) | Total (n = 324334) | P value |
|---|---|---|---|---|---|
| Age | mean (sd) median | 55.805 (8.051) 57 | 61.08 (6.121) 62 | 55.831 (8.051) 57 | <0.001 |
| Sex | Female | 180,245 (55.848) | 812 (50.973) | 181,057 (55.824) | <0.001 |
| Sex | Male | 142496 (44.152) | 781 (49.027) | 143,277 (44.176) | |
| Region | London | 38,499 (11.929) | 144 (9.040) | 38,643 (11.915) | <0.001 |
| Region | Wales | 14300 (4.431) | 64 (4.018) | 14,364 (4.429) | |
| Region | North West | 46327 (14.354) | 279 (17.514) | 46,606 (14.370) | |
| Region | North East | 37438 (11.600) | 196 (12.304) | 37,634 (11.603) | |
| Region | Yorkshier and Humber | 49346 (15.290) | 218 (13.685) | 49,564 (15.282) | |
| Region | West Midlands | 28198 (8.737) | 118 (7.407) | 28,316 (8.731) | |
| Region | East Midlands | 22512 (6.975) | 98 (6.152) | 22,610 (6.971) | |
| Region | South East | 29875 (9.257) | 131 (8.223) | 30,006 (9.252) | |
| Region | South West | 29594 (9.170) | 135 (8.475) | 29,729 (9.166) | |
| Region | Scotland | 26652 (8.258) | 210 (13.183) | 26,862 (8.282) | |
| Townsend deprivation index | [-6.26,-3.73] | 80,731 (25.044) | 281 (17.640) | 81,012 (25.008) | <0.001 |
| Townsend deprivation index | (-3.73,-2.32] | 80663 (25.023) | 300 (18.832) | 80,963 (24.993) | |
| Townsend deprivation index | (-2.32,0.128] | 80614 (25.008) | 375 (23.540) | 80,989 (25.001) | |
| Townsend deprivation index | (0.128,11] | 80347 (24.925) | 637 (39.987) | 80,984 (24.999) | |
| Townsend deprivation index | missing | 386 | 0 | 386 | |
| BMI | Normal | 114,815 (35.673) | 575 (36.369) | 115,390 (35.676) | 0.817 |
| BMI | Overweight | 137889 (42.842) | 674 (42.631) | 138,563 (42.841) | |
| BMI | Obese | 69154 (21.486) | 332 (20.999) | 69,486 (21.483) | |
| BMI | missing | 883 | 12 | 895 | |
| WHR | <=0.796 | 80,958 (25.126) | 251 (15.816) | 81,209 (25.080) | <0.001 |
| WHR | (0.796,0.864] | 80432 (24.963) | 365 (22.999) | 80,797 (24.953) | |
| WHR | (0.864,0.927] | 80633 (25.025) | 430 (27.095) | 81,063 (25.035) | |
| WHR | >0.927 | 80185 (24.886) | 541 (34.089) | 80,726 (24.931) | |
| WHR | missing | 533 | 6 | 539 | |
| Smoking status | Never | 180,665 (56.154) | 269 (16.993) | 180,934 (55.962) | <0.001 |
| Smoking status | Previous | 108576 (33.747) | 649 (40.998) | 109,225 (33.783) | |
| Smoking status | Current | 32492 (10.099) | 665 (42.009) | 33,157 (10.255) | |
| Smoking status | missing | 1008 | 10 | 1018 | |
| Alcohol intake frequency | Never | 19,558 (6.064) | 156 (9.805) | 19,714 (6.082) | <0.001 |
| Alcohol intake frequency | Special occasions only | 32815 (10.174) | 191 (12.005) | 33,006 (10.183) | |
| Alcohol intake frequency | 1-3 Times/month | 36153 (11.209) | 136 (8.548) | 36,289 (11.196) | |
| Alcohol intake frequency | 1-2 Times/week | 86049 (26.680) | 372 (23.382) | 86,421 (26.664) | |
| Alcohol intake frequency | 3 or 4 Times/week | 79493 (24.647) | 312 (19.610) | 79,805 (24.623) | |
| Alcohol intake frequency | Daily or almost daily | 68455 (21.225) | 424 (26.650) | 68,879 (21.251) | |
| Alcohol intake frequency | missing | 218 | 2 | 220 | |
| Hypertension | No | 277,358 (85.938) | 1,196 (75.078) | 278,554 (85.885) | <0.001 |
| Hypertension | Yes | 45383 (14.062) | 397 (24.922) | 45,780 (14.115) | |
| Fasting time | mean (sd) median | 3.754 (2.395) 3 | 4.11 (2.918) 3 | 3.755 (2.398) 3 | <0.001 |
| Fasting time | missing | 8 | 0 | 8 | |
| TG | mean (sd) median | 1.692 (0.982) 1.437 | 1.812 (1.028) 1.574 | 1.692 (0.982) 1.438 | <0.001 |
| Glucose | mean (sd) median | 4.987 (0.823) 4.9 | 4.965 (0.77) 4.901 | 4.987 (0.823) 4.9 | 0.296 |
| TyG index | mean (sd) median | 8.667 (0.541) 8.638 | 8.739 (0.529) 8.722 | 8.668 (0.541) 8.639 | <0.001 |
| TC | mean (sd) median | 5.786 (1.087) 5.737 | 5.675 (1.124) 5.65 | 5.786 (1.087) 5.737 | <0.001 |
| TC | missing | 79 | 0 | 79 | |
| HDL | mean (sd) median | 1.477 (0.38) 1.429 | 1.423 (0.386) 1.368 | 1.476 (0.38) 1.428 | <0.001 |
| HDL | missing | 68 | 0 | 68 | |
| LDL | mean (sd) median | 3.624 (0.832) 3.582 | 3.55 (0.869) 3.534 | 3.623 (0.832) 3.582 | <0.001 |
| LDL | missing | 455 | 1 | 456 | |
| HbA1c | Normal | 296,039 (96.406) | 1,406 (92.744) | 297,445 (96.388) | <0.001 |
| HbA1c | High | 11037 (3.594) | 110 (7.256) | 11,147 (3.612) | |
| HbA1c | missing | 15665 | 77 | 15742 |
sd, standard deviation; BMI, Body mass index; WHR, waist-hip ratio; TC, total cholesterol; TG, triglyceride; TyG index, Triglyceride-glucose index; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; HbA1c, glycated hemoglobin; TyG index, triglyceride-glucose index.