Figure 5.

Lnc-THOR shRNA inhibits A549 xenograft tumor growth in nude mice. A549 xenograft-bearing nude mice were subject to intratumoral injection of Lnc-THOR shRNA (“sh-S1”) AAV or the scramble control shRNA (“shC”) AAV. The virus was injected daily for seven consecutive days; Tumor volumes (A) and mice body weights (D) were recorded every seven days for six rounds (total 42 days, “Day-0” to “Day-42”); The estimated daily tumor growth (in mm³ per day) was calculated (B). At Day-42 mice were sacrificed and A549 xenografts were isolated and weighed (C). At experimental Day-7 and Day-14, one tumor of each group was isolated, expression of Lnc-THOR and listed mRNAs (E) was tested by qRT-PCR assays. Data were presented as mean ± standard deviation (SD). *P < 0.05 vs. “shC” group.