Table 1.
Overview study design.
| Day | PSMA PET | CT | PSMA ARG | |||
|---|---|---|---|---|---|---|
| n | (GBM | sham) | n | (GBM | sham) | n | (GBM | sham) | |
| Dynamic imaging | ||||||
| 15a | 3 | (2 | 1) | 7 | (5 | 2) | 2 | (2 | 0) |
| 18 | 4 | (2 | 2) | 4b | (2 | 2) | 2 | (2 | 0) |
| 7 | (4 | 3) | 11 | (7| 4) | 4 | (4 | 0) | |
| Longitudinal imaging | ||||||
| 4c | 8 | (5 | 3) | 12 | (8 | 4) | − | |
| 8 | 12 | (8 | 4) | 12 | (8 | 4) | − | |
| 11 | 12 | (8 | 4) | 12 | (8 | 4) | − | |
| 15 | 12 | (8 | 4) | 12 | (8 | 4) | 1 | (0 | 1) |
| 18c | 10 | (7 | 3) | 11d | (8 | 3) | 8 | (6 | 2) |
| 22 | 2 | (1 | 1) | 2 | (1 | 1) | 2 | (1 | 1) |
| 56 | (37 | 19) | 61 | (41 | 20) | 11 | (7 | 4) | |
| Competitive binding | ||||||
| 16 | 2 | (2 | 0) | − | 2 | (2 | 0) | |
| Total | 65 | (43 | 22) | 72 | (48 | 24) | 17 | (13 | 4) |
aDue to technical difficulties only 3 out of 7 PET scans could be acquired successfully. CTs were performed as planned. bCTs were performed the day prior to PET scans. cFrom the total of 12 mice (8 GBM, 4 sham) in the longitudinal imaging cohort the measurements of 4 mice (3 GBM, 1 sham) on day 4 and 1 GBM mouse on day 18 were excluded from statistical analysis due to incomplete data acquisition or tracer injection dOne mouse had to be euthanized after CT and received no PET.