Figure 5.

Therapeutic efficacy and toxicity profiles of DOX-loaded micelles in U-87 MG tumor bearing mice. Body weight changes (A), Kaplan–Meier’s survival curve (B), in vivo tumor growth inhibition (C) of U-87 MG tumor bearing mice after intravenous treatment of different DOX formulations (5 mg kg^–1 each dose for a total of seven doses) (n = 5). Data are expressed as means ± SD. *p < .05, **p < .01 analyzed by two-way ANOVA or log rank test. (D) Histology (HE) and immunohistochemical staining (Ki67 and TUNEL) of tumor tissues. Scale bar: 100 μm. (E) Histological analysis (HE staining) of other major organs excised from treated mice. Scale bar: 200 μm.