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. 2021 Nov 29;28(1):2495–2509. doi: 10.1080/10717544.2021.2008052

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Therapeutic efficacy and toxicity profiles of DOX-loaded micelles in SK-HEP-1 tumor bearing mice. In vivo tumor growth inhibition (A) and tumor weight (B) of SK-HEP-1 tumor bearing mice after intravenous administration of different DOX formulations (2.5 mg kg^–1 each dose for a total of seven doses) (n = 5).(C) Histology (HE) and immunohistochemical staining (Ki67 and TUNEL) of tumor tissues. Scale bar: 100 μm. (D) Histological images (HE staining) of hearts excised from treated mice. The intracytoplasmic vacuolation and the degradation of muscle fibers were marked by white circle and black arrows, respectively. Scale bar: 100 μm. (E) Serum chemistry analysis of mice treated with different DOX formulations, including hepatic function (ALT and AST), renal function (UREAL and BUN), and cardiac toxicity (F, CK and LDH) (n = 5). Data are expressed as means ± SD. *p < .05, **p < .01, ***p < .001 analyzed by one-way ANOVA or two-way ANOVA.