Table 1.
Physicochemical characterization of blank and DOX/DiD-labeled micelles.
| Drug loading | Weight ratio of drug/polymer | DLC (wt%)a | DLE (%)a | Diameter (nm)b | Diameter (nm)c | PDIc |
|---|---|---|---|---|---|---|
| Blank | 65 | 126.0 | 0.105 | |||
| DOX | 1:10 | 6.8 | 73.0 | |||
| DOX | 2:10 | 7.8 | 42.3 | 120 | 144.8 | 0.147 |
| DOX | 3:10 | 7.7 | 27.8 | |||
| DOX | 4:10 | 7.3 | 19.7 | |||
| DiD dye | 2:10 | 7.3 | 39.6 | 172.0 | 0.142 |
a
Drug loading capacity was determined by ultraviolet quantitative analysis.
b
Average diameter of micelles was determined by TEM.
c
Intensity-average diameter of micelles was measured by DLS.