. 2021 Nov 29;28(1):2510–2524. doi: 10.1080/10717544.2021.2008051

Table 3.

Statistical analysis of the experimental data with ANOVA and the predicted and observed results of the optimized EPL-NCs.

Response	F-value	Model p value	Lack of fit	Lack of fit p value	R ²	Adjusted R²	Predicted mean value	Range for mean values at 95% confidence	Obtained value	Error (%)
Nanocrystal size (nm)	151.24	<.0001	1.18	.4053	0.9913	0.9847	45.2	42.94–47.46	46.8 ± 0.5	3.5
Dissolution efficiency (%)	112.46	<.0001	0.516	.6254	0.9912	0.9824	95.8	91.01–100.59	96.0 ± 1.5	0.2

The polynomial equations generated after the statistical analysis are as follow:

$Nanocrystal size = + 5.23 A + 5.68 B - 5.97 A B - 0.3330 A C - 0.7776 A D - 1.31 B D + 3.54 A B D .$

$Dissolution efficiency = + 69.33 A + 61.05 B + 91.33 A B + 2.43 A C + 5.39 A D + 3.01 B C + 11.12 B D + 13.20 A B C .$

p < .05 represents statistically significant difference. For the obtained values, data are presented as mean ± S.D. (n = 3).

Error (%)=(obtained value – predicted value)/predicted value × 100.