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. 2021 Nov 21;10(1):2173–2182. doi: 10.1080/22221751.2021.1997074

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Virus load, pathology and immunoreactivity in the lungs. Animals were euthanized on day 7 post-infection and a section from each lung lobe was collected and analyzed for vRNA, sgRNA and infectious virus. Results of each assay were combined to look at the lungs in total (A-C). Significant differences were detected in lungs in both vRNA and sgRNA (D, multiple unpaired t-test, p-value <0.05 and E, multiple unpaired t-test, p-value <0.05) but not in infectious virus (C). Multiple unpaired t-tests were used to compare the two groups for statistical significance. Pathology and immunoreactivity in the lungs (D-K). Minimally thickened and inflamed alveolar septa with multifocal pneumocyte immunoreactivity in the D614G and B.1.1.7 samples (H&E (D,F) and IHC (H,J) = 100x; H&E (E,G) and IHC I,K) = 400x.).