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. 2021 Nov 17;11:769272. doi: 10.3389/fonc.2021.769272

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Copyright © 2021 Zhou, Zou, Kuang, Yan, Zhao and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) images of a 52-year-old female patient, defined as tumor microenvironment immune type (TMIT)-I tumor. (A) MIP figure, (B–D) CT, PET, PET/CT fusion images. A nodule was in the lower lobe of the left lung (arrow) with markedly increased radioactivity, SUVmax: 10.3, GLRLM_LRHGE: 382, GLZLM_SZE: 0.682, and GLCM_Contrast: 14.6. The surgical pathology: poorly moderately differentiated squamous cell carcinoma. (E) High programmed death-ligand 1 (PD-L1) expression. (F) Programmed death-1 (PD-1) tumor-infiltrating lymphocytes (TILs) high density. (G) CD8+ TILs high density.