Figure 7.

IRF8^R294C mice upon NDV infection are inefficient in pDC activation. Mice infected in 6(A) were checked for status of costimulatory molecules among splenic CD11c⁺SiglecH⁺ pDCs. Flow cytometric analysis of surface markers CD40 (A), CD86 (B), CD80 (C), and quantitation of expression of the respective markers (D–F) and histogram (G) are shown. Data (D–F) shown are mean value with error bar representing + SEM and ***p < 0.001 (n= 6 mice per group). Data (A–C, G) shown are representative of each group (n= 6 mice per group). p value obtained from Student’s t test.