Figure 8.

Schematic model of Irf8^R294C -mediated impairment in immune response. Upon NDV infection, IRF8^WT induces type I IFN promoter and transcription initiates. Type I IFN further results in production of downstream ISGs and pDC activation. Thus, together, type I IFN and ISGs restrict viral replication and mount successful immune response. Whereas, IRF8^R294C fails to induce type I IFN promoter, and transcription does not take place. So, the absence of type I IFN leads to impaired pDC activation and abrogation of production of ISGs concomitant with increased NDV burden. Thus, IRF8^R294C results in dysregulated immune response.