TABLE 5.

TM-align and ConSurf predictions.

S.No	rsID	Substitution	TM-score	RMSD	ConSurf (Score)
1	rs199927753	P47H	0.78370	4.49	Exposed (1)
2	rs761335280*	C155Y	0.22707	8.27	Buried and Highly conserved (9)
3	rs200645879	Q374H	0.80480	4.09	Exposed (6)
4	rs778652791	V382F	0.7844	4.41	Buried (7)
5	rs144403520	S384I	0.87603	3.22	Exposed (7)
6	rs768663589*	G425R	0.20968	8.44	Exposed and Highly conserved (9)
7	rs141585544	N439K	0.70496	3.68	Exposed and Highly conserved (9)
8	rs267604453	E440K	0.77840	3.89	Buried and Highly conserved (9)
9	rs199896192	L531Q	0.75460	4.27	Buried (8)
10	rs764770086	A547V	0.86956	3.48	Buried and Highly conserved (9)
11	rs145769990	P553L	0.86384	3.67	Exposed (6)
12	rs376154774	S627Y	0.79299	3.62	Exposed and Highly conserved (8)

*SNPs having lowest TM-score, highest RMSD value, and are in highly conserved positions.