Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Oct 26;60(1):351–359. doi: 10.1002/anie.202010187

Figure 4.

Figure 4.

ICG-PEG45 detects RCC metastasis with high specificity. a) RCC could metastasize to brain, bone and lung. b) In vivo noninvasive bioluminescence images and fluorescence images of mice bearing RCC metastatic tumors at 24 h after injection ICG-PEG45. BLI, bioluminescence images. Fl, fluorescence. R, right, L, left. c) Ex vivo images of tumor near spine and brain at 24 h post injection of ICG-PEG45. BLI, bioluminescence images. Fl, fluorescence. d) Ex vivo images of upper limbs and lower limbs at 24 h post injection of ICG-PEG45. BLI, bioluminescence images. Fl, fluorescence. e) (left) In vivo noninvasive images of other mice bearing RCC metastatic tumors at 24 h post injection of ICG-PEG45. (right) Ex vivo FL images of lower limbs (with and without muscle) and color images (without muscle; f) at 24 h post injection of ICG-PEG45 as well as H&E pathology images. The images of upper limbs were in Figure S17.