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Submandibular salivary glands (SSG) possessed the lowest permeability (except for brain) and highest NPs retention for the both NPs. (a) Accumulation of GS-AuNPs and GS-AgNPs in SSG at 5 mins 3 and 24 h p.i.. (b) NPs’ permeabilities in various organs (defined as organs-to-blood ratio at 5 min p.i.). (c) Pharmacokinetics profiles and Vd (insert) of the both NPs. (D) Retentions of the two NPs (defined as the ratio of 24 h / 5 min accumulation in each organs).
