Mechanism scheme showing the permeability, retention and clearance of GS-AuNPs (brown) and GS-AgNPs (blue) in SSG. Compare with GS-AuNPs, due to the higher vascular permeability, GS-AgNPs can more easily extravasate from blood vessels into the SSG, be uptaken by striated and excretory duct cells and finally eliminated into saliva. Moreover, the uptake of NPs by acinar cells and intercalated duct cells is blocked due to the presence of myoepithelial cells with tight junctions.