Table 2.
Characteristics of all 4 study groups before and after 12 weeks of treatment with exenatide or diet.
| Exenatide High Responders (n = 42) | Exenatide Low responders (n = 33) | |||||
|---|---|---|---|---|---|---|
| Week 0 | Week 12 | p | Week 0 | Week 12 | p | |
| BMI (kg/m2) | 35.8 ± 5.2 | 33.5 ± 4.7 | <0.0005* | 36.5 ± 5.0 | 35.8 ± 5.0 | 0.0008* |
| Weight (kg) | 93.9 ± 14.9 | 87.7 ± 13.7 | <0.0005* | 98.5 ± 13.9 | 96.6 ± 13.6 | <0.0005* |
| Systolic BP (mmHg) | 122.1 ± 12.6 | 119.0 ± 12.6 | 0.12 | 124.7 ± 15.5 | 124.4 ± 15.8 | 0.90 |
| Diastolic BP (mmHg) | 69.5 ± 9.3 | 72.6 ± 10.9 | 0.08 | 72.8 ± 9.3 | 75.0 ± 13.7 | 0.30 |
| Heart Rate (bpm) | 68.1 ± 11.3 | 68.9 ± 11.7 | 0.58 | 68.0 ± 8.8 | 72.8 ± 9.7 | 0.02* |
| Total Cholesterol (mg/dL) | 196.8 ± 34.3 | 177.9 ± 30.1 | <0.0005* | 188.4 ± 38.9 | 180.0 ± 35.6 | 0.01* |
| HDL Cholesterol (mg/dL) | 61.0 ± 19.3 | 52.9 ± 15.9 | 0.0005* | 55.8 ± 12.0 | 53.9 ± 11.2 | 0.20 |
| LDL Cholesterol (mg/dL) | 115.6 ± 30.8 | 106.1 ± 27.1 | 0.0045* | 110.8 ± 32.5 | 105.0 ± 28.9 | 0.04* |
| Triglycerides (mg/dL) | 111.0 ± 61.5 | 94.1 ± 42.6 | 0.03* | 100.4 ± 37.8 | 101.2 ± 52.9 | 0.89 |
| Insulin (mIU/mL) | 12.2 ± 7.0 | 11.9 ± 8.8 | 0.90 | 11.0 ± 6.5 | 10.4 ± 4.9 | 0.43 |
| Waist Circumference (cm) | 111.8 ± 10.7 | 105.0 ± 9.5 | <0.0005* | 111.6 ± 11.9 | 110.6 ± 11.6 | 0.54 |
| Resting Energy Expenditure (kCal/d) | 1548.9 ± 224.4 | 1411.0 ± 184.5 | 0.0001* | 1556.3 ± 174.3 | 1560.2 ± 182.5 | 0.85 |
| Percent Body Fat (%) | 43.7 ± 4.1 | 43.3 ± 4.3 | 0.49 | 43.8 ± 4.6 | 43.6 ± 4.1 | 0.74 |
| Thermic Effect of Food | 4.4 ± 2.0 | 3.5 ± 2.4 | 0.04* | 4.3 ± 2.2 | 2.4 ± 2.8 | 0.006* |
| Diet High Responders (n = 25) | Diet Low Responders (n = 8) | |||||
| Week 0 | Week 12 | p | Week 0 | Week 12 | p | |
| BMI (kg/m2) | 35.1 ± 5.2 | 32.2 ± 4.3 | <0.0005* | 34.4 ± 4.5 | 34.6 ± 4.6 | 0.67 |
| Weight (kg) | 94.7 ± 13.6 | 87.5 ± 11.9 | <0.0005* | 91.6 ± 11.9 | 92.2 ± 12.2 | 0.55 |
| Systolic BP (mmHg) | 126.0 ± 11.8 | 117.6 ± 14.0 | 0.002* | 117.1 ± 15.3 | 114.4 ± 10.5 | 0.33 |
| Diastolic BP (mmHg) | 71.7 ± 9.3 | 69.7 ± 8.6 | 0.35 | 67.4 ± 5.8 | 65.8 ± 9.8 | 0.46 |
| Heart Rate (bpm) | 68.1 ± 9.1 | 66.6 ± 9.8 | 0.50 | 69.6 ± 6.1 | 71.3 ± 7.4 | 0.65 |
| Total Cholesterol (mg/dL) | 193.5 ± 28.0 | 180.1 ± 38.7 | 0.01* | 183.9 ± 39.0 | 172.9 ± 26.2 | 0.28 |
| HDL Cholesterol (mg/dL) | 59.8 ± 11.3 | 52.5 ± 12.4 | 0.0003* | 61.4 ± 12.4 | 61.1 ± 17.4 | 0.95 |
| LDL Cholesterol (mg/dL) | 113.0 ± 25.6 | 111.3 ± 34.2 | 0.64 | 101.7 ± 27.7 | 94.4 ± 26.5 | 0.51 |
| Triglycerides (mg/dL) | 103.2 ± 47.1 | 82.4 ± 34.3 | 0.002* | 102.6 ± 57.8 | 85.7 ± 49.1 | 0.03 |
| Insulin (mIU/mL) | 11.4 ± 9.9 | 7.5 ± 5.3 | 0.03* | 10.4 ± 4.8 | 11.1 ± 7.0 | 0.75 |
| Waist Circumference (cm) | 111.6 ± 11.30 | 102.7 ± 17.6 | 0.004* | 106.8 ± 10.7 | 108.9 ± 10.4 | 0.16 |
| Resting Energy Expenditure (kCal/d) | 1542.5 ± 194.6 | 1386.6 ± 116.9 | 0.0004* | 1463.9 ± 217.5 | 1447.9 ± 248.9 | 0.78 |
| Percent Body Fat (%) | 43.8 ± 3.8 | 42.0 ± 4.6 | 0.02* | 43.7 ± 5.2 | 43.0 ± 5.1 | 0.39 |
| Thermic Effect of Food | 4.5 ± 2.0 | 4.1 ± 2.0 | 0.56 | 4.2 ± 2.0 | 4.2 ± 2.2 | 0.96 |
Values are mean +/- SD. *p values < 0.05 are considered significant.