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. 2021 Nov 17;12:645548. doi: 10.3389/fimmu.2021.645548

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Copyright © 2021 Tsitoura, Trachalaki, Vasarmidi, Mastrodemou, Margaritopoulos, Kokosi, Fanidis, Galaris, Aidinis, Renzoni, Tzanakis, Wells and Antoniou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COL1A1 expression in relation to progression and mortality. Spearman correlation coefficient between relative mRNA expression of COL1A1 and FVC decline in 12 months in: (A) all ILDs combined (IPF and other ILDs), (B) IPF and (C) ILDs other than IPF. Comparison of COL1A1 relative mRNA expression in progressors (≥10% FVC decline at 12 months) and non progressors (<10% FVC decline at 12 months in (D) all ILDs, (E) IPF and (F) ILDs other than IPF unpaired T-test or Mann-Whitney tests. Kaplan Mayer Survival curves of patients with high (above the ROC curve-defined cut-off) and low expression of COL1A1 mRNA expression in: (G) all ILDs combined, (H) IPF and (I) ILDs other than IPF. (*p < 0.05). HR, Hazard ratio).