Table 1.
Comparison of baseline demographic, clinical, laboratory and radiological features between pediatric ADS MOG-Ab positive (+) and MOG-Ab negative (–).
|
ADS MOG-Ab+ |
ADS MOG-Ab- |
p -value | |
|---|---|---|---|
| Number | 15 | 22 | |
| Female, n (%) | 5 (33%) | 9 (40%) | ns |
| Age at sampling, median (range), years | 9.8/2.17–17.5 | 14.7/9–17 | 0.002 |
| MOG-Ab titre, median (range) | 0.12/0.04–0.69 | / | |
| CSF IgG oligoclonal bands (%) | 4/15 (27%) | 15/22 (70%) | 0.013 |
| Abnormal brain MRI (%) | 11/15 (75%) | 19/22 (87%) | ns |
| Abnormal spinal cord MRI (%) | 9/22 (62%) | 13/22 (59%) | ns |
| Encephalopathy at onset | 8/15 (53%) | 1/22 (4.5%) | 0.006 |
| Optic Neuritis at onset (%) | 7/15 (47%) | 11/22 (50%) | ns |
| Myelitis at onset (%) | 8/15 (53%) | 14/22 (64%) | ns |
| Brainstem at onset (%) | 7/15 (47%) | 7/22 (32%) | ns |
| Multifocal onset | 8/15 (53%) | 6/22 (27%) | 0.09 |