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. 2021 Nov 10;12:738056. doi: 10.3389/fimmu.2021.738056

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Copyright © 2021 Wang, Wu, Hsu, Pan, Shu and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of TIM3 on CD4+ and CD8+ lymphocytes according to disease status. (A) Case demonstration and (B, C) scatter plots between healthy controls and patients with Mycobacterium avium complex-lung disease (MAC-LD) are shown. The lymphocyte group was discriminated by forward scatter (FSC) and side scatter (SSC). CD4+ and CD8+ cells were then gated within the lymphocytes and TIM3 was measured. The cross bars in the scatter plots are median values. We compared the data by Mann–Whitney U test. One star indicates p < 0.05; and two stars mean p < 0.01.