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. 2021 Dec 2;31(1):40–51. doi: 10.1007/s00044-021-02826-2

Table 2.

Binding energies of glycyrrhizic acid and glycyrhhizin with SARS-CoV-2 target proteins

Target/PDB Code Glycyrrhizic Acid [55] Glycyrrhizin [56]
MPro / 7K3T −8.7 −8.1
PLPro / 6W9C −8.2 −7.9
RdRp / 7BV2 −9.9 –
N / 6YVO – −7.9
S / 6VXX −9.3 –
Human ACE2 / 7A98 −9.5 –

MPro-Main Protease (3CLPro, Chymotripsin-like Protease); PLPro-Papain-like Protease; RdRp-RNA-dependent RNA polymerase; N-Nucleocapsid protein; S-Spike protein; Human ACE2-Angiotensin Converting Enzyme 2 (human host cell surface)