. 2021 Dec 2;31(1):40–51. doi: 10.1007/s00044-021-02826-2

Table 4.

Binding interactions common to flavonoids and glycyrrhizic acid in RdRp, and flavonoids and glycyrrhizinic acid in ACE2 [55, 63]

RdRp (PDB Codes 6M71 and 7BV2) [41, 89]
Glycyrrhizic Acid [55]	Flavonoid^a/Flavonoid Glycoside^b [63]	Glycyrrhzinic Acid [55]
Arg⁵⁵⁵, Ser⁶⁸²	Apigenin^a	Ala³⁴⁸
Arg⁵⁵⁵, Ile⁵⁴⁸	Apigenin-7-O-glucoside^b	Ala³⁴⁸, Arg³⁹³, Asn³⁹⁴
Arg⁵⁵⁵	Galangin^a	Asn³⁹⁴, Asp³⁵⁰, Arg³⁹³
Arg⁵⁵⁵, Ser⁶⁸²	Hesperetin^a	Ala³⁴⁸, Arg³⁹³, Asn³⁹⁴
Lys⁵⁴⁵, Ile⁵⁴⁸	Hesperidin^b	Tyr³⁸⁵, Ala³⁴⁸, Arg³⁹³
Arg⁵⁵⁵	Kaempferol^a	Asn³⁹⁴
Ile⁵⁴⁸	Luteolin^a	Ala³⁴⁸
Ile⁵⁴⁸	Luteolin-7-O-glucoside^b	Glu⁴⁰²
Ser⁶⁸²	Naringenin^a	–
Ser⁵⁴⁹, Asp⁶²³	Naringin^b	Ala³⁴⁸, Arg³⁹³
Ser⁶⁸²	Quercetin^a	Ala³⁴⁸
Ile⁵⁴⁸, Asp⁶²³, Lys⁵⁵¹, Arg⁵⁵⁵	Rutin^a	Asn³⁹⁴

^aFlavonoid

^bFlavonoid glycoside