FIG 1.

Screening of human-associated bacteria for the production of anti-SARS-CoV-2 active metabolites. (a) Schematic for the construction of a fractionated culture broth extract library and antiviral screening. (b, i) Anti-SARS-CoV-2 activity of fractionated culture broth extracts from 50 human-associated bacteria. n = 3. (b, ii and iii) Antiviral active metabolites were isolated from column fractions that showed reproducible antiviral activity. n = 3. (b, iv) Anti-SARS-CoV-2 activity and cytotoxicity of each purified metabolite in Huh-7.5 cells. n = 3; data are mean ± SD.