TABLE 1.
Anti-SARS-CoV-2 activity of naturally occurring IPA, tryptamine, and BIP structural relativesa
| Structure | IC50 (μM) |
|---|---|
| IPA-related structures | |
| N6-(Δ2-isopentenyl) adenosine | 2 |
| Adenine | >250 |
| N6-(Δ2-isopentenyl) adenine | >250 |
| trans-Zeatin | >250 |
| Adenosine | >250 |
| N6-methyl adenosine | >250 |
| N6,N6-simethyl adenosine | >250 |
| trans-Zeatin riboside | >250 |
| Tryptamine-related structures | |
| Tryptamine | 33 |
| Tryptophan | >250 |
| Indole-3-propionic acid | >250 |
| N-Acetyltryptamine | >250 |
| Phenylethylamine | 132 |
| Tyramine | >250 |
| Pyrazines | |
| BIP | 70 |
| IMP | >250 |
| BPP | >250 |
| PMP | >250 |
a
n = 3; data are mean IC50 values.