TABLE 4.

Descriptions of significantly different brain regions in the CBF-ReHo ratio between PD-MCI group and HC and PD-NC groups.

Brain regions (AAL)	Peak MNI coordinates (mm)			Peak T value	Cluster size (mm3)
	X	Y	Z
PD-MCI > HC
Left putamen	−21	21	−9	6.10	272
Right putamen	21	24	−9	5.25	170
Left lingual gyrus	−12	−69	0	5.57	158
Right lingual gyrus	15	−66	0	4.16	59
Left postcentral gyrus	−48	−21	39	5.86	348
PD-MCI < HC
Right superior temporal gyrus	33	12	−45	−4.08	23
Left parahippocampal gyrus	−6	36	−27	−6.42	188
Right parahippocampal gyrus	12	9	−21	−5.46	59
Right inferior frontal gyrus	36	21	−18	−3.88	28
Left middle temporal gyrus	−63	−24	−15	−3.98	44
Right middle temporal gyrus	63	−27	−9	−5.70	173
PD-MCI > PD-NC
Left lingual gyrus	−12	−78	12	3.75	26

These clusters are referred to multiple comparisons correction using the FWE rate (a cluster-defining threshold of P = 0.001 and a corrected cluster significance of P < 0.05).

CBF, cerebral blood flow; ReHo, regional homogeneity; HC, healthy control; PD, Parkinson’s disease; NC, normal cognition; MCI, mild cognitive impairment; AAL, automated anatomical labeling; MNI, Montreal Neurological Institute; FWE, familywise error.