Table 4.
Discrimination of each predictive model for outcomes using C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).
| Predictive Models | C-index | P-Value | NRI | P-Value | IDI | P-Value |
|---|---|---|---|---|---|---|
| All-cause death | ||||||
| Established risk factors | 0.767 | <0.001 | Reference | Reference | ||
| +CAR | 0.776 | <0.001 | 0.451 | 0.001 | 0.013 | 0.049 |
| Cardiovascular | ||||||
| death | ||||||
| Established risk factors | 0.812 | <0.001 | Reference | Reference | ||
| +CAR | 0.833 | <0.001 | 0.386 | 0.006 | 0.010 | 0.042 |
| MACE | ||||||
| Established risk factors | 0.587 | 0.003 | Reference | Reference | ||
| +CAR | 0.603 | <0.001 | 0.182 | 0.129 | 0.002 | 0.443 |
Established risk factors included age, sex, smoking, alcohol drinks, hypertension, diabetes mellitus, prior myocardial infarction, cholesterol, CKMB, LVEF, pro-BNP. AUC, area under curve; IDI, integrated discrimination improvement; NRI, net reclassification improvement; CAR, C-reactive protein to albumin ratio; BMI, body mass index; MI, myocardial infarction; DBP, diastolic blood pressure; SBP, systolic blood pressure; LDL, Low-density lipoprotein; HDL, High-density lipoprotein; hsCRP, high sensitivity C-reactive protein; LVEF, left ventricular ejection fraction; CK-MB, creatine kinase isoenzymes MB; pro-BNP, pro-B-type natriuretic peptide; TSH, thyroid stimulating hormone; ACEI, angiotensin-converting enzyme inhibition; ARB, angiotensin receptor blocker.