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. 2021 Nov 15;12:749074. doi: 10.3389/fimmu.2021.749074

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Copyright © 2021 Neves, Wong, Aimanianda, Simenel, Guijarro, Walls, Willment, Gow, Munro, Brown and Lopes-Bezerra

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sporothrix schenckii and Sporothrix brasiliensis yeasts stimulate pentraxin 3 (PTX3) secretion by human monocyte-derived macrophages (hMDMs). (A) Only in the medium supplemented with whole human serum (wHS), S. schenckii or S. brasiliensis yeasts stimulated the secretion of PTX3 by hMDMs but not in the medium containing inactivated human serum (iHS), suggesting that the thermolabile complement system plays a role during this process. Statistical analysis was performed by ANOVA with Tukey’s multiple comparison posttest (***p < 0.001). (B) Complement receptor-3 (CR3) crosstalks with Toll-like receptor (TLR)4 in stimulating PTX3 secretion by hMDMs upon interaction with S. schenckii or S. brasiliensis yeasts. Statistical analysis was performed by ANOVA with Tukey’s multiple comparison posttest (*p < 0.05).