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. 2021 Nov 16;9:780461. doi: 10.3389/fcell.2021.780461

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Copyright © 2021 Lin, Wang, Wang, Shao, Yang, Cao, Feng, Gao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothesis graph. With the accumulation of senescent cells, the inflammatory SASP remodels the TIME by recruiting immunosuppressive cells, thus promoting tumor cell invasion through immunosurveillance, proliferation, and metastasis and contributing to poor prognosis in LUAD.