Figure 5.
Construction of the final SAGA classifier
(A) Performance profile of the SVM-RFE procedure for the complete set of 152 samples. The filled circle represents the predictor subset with the highest performance comprised of the 20 most important predictors. (B) Performance profile of the SVM-GA procedure for the complete set of 152 samples over 40 generations of the GA. (C) Principal-component analysis (PCA) of 152 samples with known IVIM activity on the 11 optimal probes found by SVM-GA. (D) PCA of 152 samples with known IVIM activity on 11 randomly selected probes of 36,226 annotated probes. (E) Heatmap representing expression of the 20 genes with the highest predictive power from SVM-RFE across murine hematopoiesis.34 The boxplot below the heatmap represents the expression of genes in each column relative to the expression of all genes. LT-HSC, long-term HSC; ST-HSC, short-term HSC; MPP, multipotent progenitor; Mac/MF, macrophage; Mo, monocyte; Gran/GN, granulocyte.