Figure 1.

Adaptive NK cells from CMV seropositive healthy donors with higher frequencies of NKG2C respond to the NKG2C-KE

CMV seropositive donors were divided into groups based on expression of <10% or >10% NKG2C⁺ NK cells. These populations were then incubated for 5 h with THP1 tumor cells and stained for degranulation by CD107a (A) and IFN-γ production (B). Correlations between NKG2C frequency and degranulation or IFN-γ production are shown in (C). Graphs indicate the means ± SEMs analyzed using a 2-way ANOVA for (A) and (B). The correlation in (C) was analyzed using a linear regression analysis. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.01, ∗∗∗∗p < 0.0001.