TABLE 3.
Baseline patient and treatment characteristics of the subset of patients with lower/GEJ tumors treated with esophagectomies with cervical anastomoses (n = 44)
| Anastomotic complication | p‐value | ||
|---|---|---|---|
| Yes | No | ||
| n = 35 (79.6%) | n = 9 (20.5%) | ||
| n, (%) | n, (%) | ||
| Age at diagnosis (median year, IQR) | 56 (53–65) | 59 (54–68) | 0.83 |
| Length of follow‐up (days, IQR) | 1071 (547–3046) | 1511 (904–2191) | 0.97 |
| Male sex | 32 (91.4) | 8 (88.9) | 1.00 |
| BMI (median kg/m2, IQR) | 26.8 (24.3–29.3) | 25.8 (20.0–30.3) | 0.39 |
| Diabetes | 9 (25.71) | 1 (11.1) | 0.66 |
| History of smoking | 30 (85.7) | 7 (77.8) | 0.62 |
| Histology type | 0.81 | ||
| Adenocarcinoma | 32 (91.4) | 8 (88.9) | |
| SCC | 3 (8.6) | 1 (11.1) | |
| Location of tumor | 1.00 | ||
| Distal esophagus | 21 (60.0) | 5 (55.6) | |
| GEJ | 14 (40.0) | 4 (44.4) | |
| Group stage | 0.23 | ||
| II | 13 (37.1) | 1 (11.1) | |
| III | 22 (62.9) | 8 (88.9) | |
| Clinical T stage | 0.31 | ||
| cT1 | 0 (0.0) | 0 (0.0) | |
| cT2 | 7 (20.0) | 0 (0.0) | |
| cT3 | 28 (80.0) | 9 (100) | |
| cT4 | 0 (0.0) | 0 (0.0) | |
| Clinical N stage | 0.37 | ||
| cN0 | 10 (28.6) | 1 (11.1) | |
| cN1 | 22 (62.9) | 8 (88.9) | |
| cN2 | 3 (8.6) | 0 (0.0) | |
| cN3 | 0 (0.0) | 0 (0.0) | |
| Total RT (Gy) | 1.00 | ||
| 45.0 | 27 (77.1) | 7 (77.8) | |
| 50.4 | 8 (22.9) | 2 (22.2) | |
| Chemotherapy regimen | 0.13 | ||
| Platin/Taxol | 8 (22.9) | 3 (33.3) | |
| Platin/Fluorouracil | 23 (65.7) | 3 (33.3) | |
| Other | 4 (11.4) | 3 (33.3) | |
| Resection year (median, range) | 2009 (2008–2010) | 2009 (2008–2012) | 0.94 |
| Positive resection cancer margin | 2 (5.7) | 0 (0.0) | 1.00 |
| Distal | 2 (5.7) | 0 (0.0) | |
| Proximal | 0 (0.0) | 0 (0.0) | |
| Circumferential | 0 (0.0) | 0 (0.0) | |
| Positive Barrett's esophagus | 13 (37.1) | 2 (22.2) | 0.66 |
| Distal margin | 0 (0.0) | 0 (0.0) | |
| Proximal margin | 1 (2.9) | 0 (0.0) | |
| Interval from last RT to surgery (median days, IQR) | 39 (33–44) | 34 (32–44) | 0.47 |
Abbreviations: BMI, body mass index; Gy, gray; IQR, interquartile range; GEJ, gastroesophageal junction; Platin, cisplatin or carboplatin; RT, radiation; SCC, squamous cell carcinoma.