Table 3.
Primary and secondary outcomes at 1 year, according to the rhythm on the pre-percutaneous coronary intervention electrocardiogram
| Unadjusted |
Adjusted* |
|||||
|---|---|---|---|---|---|---|
| Outcomes | AF/flutter, n (%) (n = 437) | Sinus rhythm, n (%) (n = 8393) | HR (95% CI) | P | HR (95% CI) | P |
| Primary and secondary outcomes | ||||||
| Primary outcome | 76 (17.4) | 617 (7.4) | 2.51 (1.97–3.19) | < 0.001 | 1.68 (1.30–2.16) | < 0.001 |
| Cardiovascular death | 43 (9.8) | 274 (3.3) | 3.12 (2.26–4.31) | < 0.001 | 1.69 (1.19–2.40) | 0.003 |
| Recurrent MI | 12 (2.7) | 204 (2.4) | 1.17 (0.66–2.10) | 0.591 | 0.99 (0.55–1.79) | 0.965 |
| Cardiogenic shock | 16 (3.7) | 153 (1.8) | 2.05 (1.22–3.45) | 0.006 | 1.40 (0.80–2.48) | 0.242 |
| Class IV heart failure | 24 (5.5) | 157 (1.9) | 3.08 (2.01–4.74) | < 0.001 | 1.96 (1.25–3.07) | 0.003 |
| CVD, MI, CardShock, HF, stent thrombosis, TVR | 94 (21.5) | 909 (10.8) | 2.13 (1.72–2.64) | < 0.001 | 1.56 (1.24–1.95) | < 0.001 |
| All-cause mortality | 50 (11.4) | 327 (3.9) | 3.06 (2.27–4.12) | < 0.001 | 1.63 (1.18–2.24) | 0.003 |
| Stent thrombosis | 5 (1.1) | 166 (2.0) | 0.60 (0.24–1.45) | 0.255 | 0.47 (0.19–1.15) | 0.099 |
| Definite stent thrombosis | 4 (0.9) | 117 (1.4) | 0.67 (0.25–1.82) | 0.434 | 0.59 (0.22–1.62) | 0.307 |
| Target vessel revascularization | 23 (5.3) | 450 (5.4) | 1.03 (0.67–1.56) | 0.906 | 0.93 (0.61–1.43) | 0.753 |
| Major bleeding | 14 (3.2) | 154 (1.8) | 1.81 (1.05–3.13) | 0.033 | 1.32 (0.75–2.31) | 0.336 |
| Safety outcome | ||||||
| Stroke | 12 (2.7) | 75 (0.9) | 3.21 (1.75–5.91) | < 0.001 | 1.84 (0.95–3.58) | 0.071 |
| TIA | 1 (0.2) | 19 (0.2) | 1.06 (0.14–7.88) | 0.958 | 0.78 (0.10–5.97) | 0.808 |
| Stroke/TIA | 13 (3.0) | 93 (1.1) | 2.80 (1.57–5.01) | < 0.001 | 1.69 (0.90–3.16) | 0.102 |
| Net risk–benefit risk outcome | ||||||
| CVD, MI, CardShock, HF, stroke | 80 (18.3) | 663 (7.9) | 2.46 (1.95–3.11) | < 0.001 | 1.62 (1.26–2.08) | < 0.001 |
AF, atrial fibrillation; CardShock, cardiogenic shock; CI, confidence interval; CVD, cardiovascular disease; HF, heart failure; HR,hazard ratio; MI, myocardial infarction; TVR, target vessel revascularization; TIA, transient ischemic attack.
⁎
Adjusted for age, symptom onset (6-12 h vs < 6 h), gender, MI type, current smoking, previous hypertension, previous diabetes, previous MI, previous PCI, proximal lesion, previous stroke, and Killip class.