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. 2021 Sep 23;56(12):3049–3058. doi: 10.1038/s41409-021-01452-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Flow cytometry analysis of B cells (CD45⁺ CD19⁺) in the PB and in the different organs. The distribution of the different B cell maturation in the BM panel represents the results from pcGVHD. Data are shown as mean ± SEM. Data are collected from 4–5 independent experiments with 5–6 mice per group. *P < .05, **P < .01, and ***P < .001. 2-sided Student’s unpaired t-test UTM: untreated transplanted mice (vehicle administration); IXZ: ixazomib group; HD: healthy donor; SYG: syngeneic group; 2/4 and +10 W: weeks after starting the treatment. MZB: Marginal Zone B Cells B220⁺ CD23^{− /low}CD21⁺; T1: transitional T1 (B220⁺ CD21⁺ IgM⁺); T2: transitional T2 ⁽B220⁺ CD21⁻ IgM⁺).