Figure 7.

Screening and bioinformatics analysis of downstream target genes of the miR-122-5p that participate in RBI

(A) The significantly upregulated and downregulated genes identified in the transcriptome analysis of the hippocampus from the irradiation group, the control group, and the antagomiR-122-5p intervention group. (B) The gene set included 15 downregulated genes (Rad versus control) that were reversed by miR-122-5p inhibition (miR-122-5p versus Rad) and 42 upregulated genes (Rad versus control) that were reversed by miR-122-5p inhibition (miR-122-5p versus Rad). (C and D) Thermographic analysis of genes (15 and 42) exhibiting significant changes in expression after irradiation that were rescued by miR-122-5p inhibition (antagomiR-122-5p intervention). (E and F) KEGG pathway analysis of differentially expressed genes (15 and 42).